Famotidine is a potent and high affinity histamine H2 receptor biased inverse agonist (Kd = 14 nM, IC50 = 33 nM). Reduces basal receptor activity by 75%. Inhibits Gs-mediated pathways but acts as a partial agonist of β-arrestin recruitment (EC50 = 105 nM). Inhibits gastric acid secretion and histamine-induced mast cell activation. Also inhibits HIV replication
in vitro
.
Caractéristiques techniques
| Marque | Tocris |
|---|
| Réf. B-LABO | BL-RE-125978 |
|---|
| Réf. fabricant | 18756336 |
|---|
| Nom chimique ou matériau | 3-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]-N-(aminosulfonyl)propanimidamide |
|---|
| CAS | 76824-35-6 |
|---|
| Quantité | 100 mg |
|---|
| Cible | Histamine H2 Receptor Antagonists |
|---|
| Formule moléculaire | C<sub>8</sub>H<sub>15</sub>N<sub>7</sub>O<sub>2</sub>S<sub>3</sub> |
|---|
| Pureté | 0.98 |
|---|
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