Potent and selective PDE4B inhibitor
A 33 is a potent and selective PDE4B inhibitor (IC50 = 15 nM); exhibits >100-fold selectivity for PDE4B over 4D. Regulates cAMP in inflammatory cells. Inhibits LPS-induced TNF-α production and neutrophil accumulation in mouse lungs. Reduces microglial and neutrophil activation, and improves behavioral deficits in a traumatic brain injury model
in vivo
. Also exhibits antidepressant-like effects. Orally bioavailable.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-126021 |
| Réf. fabricant | 18796036 |
| Nom chimique ou matériau | 2-[4-[[2-(5-Chloro-2-thienyl)-5-ethyl-6-methyl-pyrimidin-4-yl]amino]phenyl]acetic acid |
| CAS | 915082-52-9 |
| Quantité | 10 mg |
| Formule moléculaire | C<sub>19</sub>H<sub>18</sub>ClN<sub>3</sub>O<sub>2</sub>S |
| Poids de la formule | 387.88 |
| Type de produit | Inhibitor |
| Pureté | 98% |
