Potent VEGFR inhibitor; also aromatase inhibitor
Vatalanib succinate is a potent VEGFR inhibitor (IC50 values are 37 and 77 nM for VEGFR-2 and -1, respectively). Inhibits proliferation, migration and survival of HUVECs
in vitro
and inhibits growth, vascularization and metastasis of tumors expressing VEGFR in mouse models. Also inhibits PDGFR-β, c-Kit and c-Fms. Potent aromatase inhibitor (IC50 = 50 nM). Orally available.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-126027 |
| Réf. fabricant | 18780919 |
| Nom chimique ou matériau | N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine succinate |
| CAS | 212142-18-2 |
| Synonyme | CGP 79787D, PTK787/ZK222584 |
| Quantité | 50 mg |
| Cible | VEGF Receptor Inhibitors |
| Formule moléculaire | C<sub>20</sub>H<sub>15</sub>ClN<sub>4</sub>.C<sub>4</sub>H<sub>6</sub>O<sub>4</sub> |
| Poids de la formule | 464.9 |
| Pureté | >99% |
