Potent and selective SUV420H1/H2 inhibitor
A 196 is a potent and selective SUV420H1/H2 inhibitor (IC50 values are 25 and 144 nM respectively) that exhibits 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. A 196 inhibits the di- and tri-methylation of H4K20me in multiple cell lines (IC50 < 1 μM).
To request the negative control for A 196, please fill out the SGC 2043 request form on the SGC website.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-126040 |
| Réf. fabricant | 18786046 |
| Nom chimique ou matériau | 6,7-Dichloro-N-cyclopentyl-4-(4-pyridinyl)-1-phthalazinamine |
| CAS | 1982372-88-2 |
| Plage de pourcentage du dosage | >98% |
| Quantité | 50 mg |
| Formule moléculaire | C<sub>18</sub>H<sub>16</sub>Cl<sub>2</sub>N<sub>4</sub> |
| Poids de la formule | Observed MW: 359.25 |
