Deoxycytidine kinase (dCK) substrate
Clofarabine is a deoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase-α and -ε and potently inhibits ribonucleotide reductase (IC50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-126044 |
| Réf. fabricant | 18777756 |
| Nom chimique ou matériau | 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine |
| CAS | 123318-82-1 |
| Plage de pourcentage du dosage | >99% |
| Quantité | 5 mg |
| Formule moléculaire | C<sub>10</sub>H<sub>11</sub>ClFN<sub>5</sub>O<sub>3</sub> |
| Poids de la formule | Observed MW: 303.68 |
