Inhibitor of the interaction between the 5-HT transporter (SERT) and neuronal nitric oxide synthase (nNOS)
ZZL-7 is a fast-acting antidepressant that enhances 5-HT (serotonin) signaling in forebrain circuits. ZZL-7 disrupts the interaction between the 5-HT transporter (SERT) and neuronal nitric oxide synthase (nNOS) in the dorsal raphe nucleus (DRN), which reduces extracellular 5-HT concentration and down-regulates 5-HT1A receptor auto-activity in the DRN. This reduced auto-inhibition enables increase in firing frequency of serotonergic neurons in the DRN and increases in 5-HT release in the medial hippocampus. ZZL-7 can readily cross the blood-brain barrier.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-126052 |
| Réf. fabricant | 30000035 |
| Nom chimique ou matériau | N-Acetyl-L-alanyl-L-valine methyl ester |
| CAS | 99141-91-0 |
| Quantité | 10 mg |
| Cible | SLC6A4/5-HTTLPR/Serotonin transporter |
| Formule moléculaire | C<sub>11</sub>H<sub>20</sub>N<sub>2</sub>O<sub>4</sub> |
| Pureté | 0.98 |
