Potent FAK inhibitor; orally bioavailable
PND 1186 is a potent FAK inhibitor (IC50 values are 1.5 and 100 nM for recombinant FAK and FAK in breast carcinoma cells, respectively). Promotes caspase activation; triggering apoptosis. Inhibits 4T1 breast carcinoma subcutaneous tumor growth and breast carcinoma cell motility. Decreases spontaneous breast to lung metastasis in pre-clinical models. Orally bioavailable.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-126093 |
| Réf. fabricant | 18728866 |
| Quantité | 50 mg |
| Formule moléculaire | C<sub>25</sub>H<sub>26</sub>F<sub>3</sub>N<sub>5</sub>O<sub>3</sub> |
| Poids de la formule | 501.51 |
| Type de produit | Inhibitor |
| Pureté | 98% |
