Tariquidar dihydrochloride is a potent P-glycoprotein (P-gp) inhibitor (IC50 = 5.1 nM). Reverses drug resistance in multiple MDR cell lines. Acts as a substrate for breast cancer resistance protein (BCRP) at low concentrations and acts as an inhibitor of BCRP when used at >100 nM concentration. Potentiates the cytotoxic effects of doxorubicin (Cat. No. 2252) and mitoxantrone (Cat. No. 4250) in vitro.
- Nom chimique ou matériau
- N-[2-[[[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]amino]carbonyl]-4,5-dimethoxyphenyl]-3-quinolinecarbxamide dihydrochloride
- CAS
- 1992047-62-7
- Quantité
- 50 mg
- Cible
- Multidrug Transporter Inhibitors
- Formule moléculaire
- C38H38N4O6.2HCl
- Poids de la formule
- 719.66
- Pureté
- >98%
