"/> Tocris Bioscience™ (+)-JQ1 maleimide | B-LABO France

Tocris Bioscience™ (+)-JQ1 maleimide

Réf. : BL-RE-126179Réf. fabricant : 18015552 10 mg
361,88 € HT

JQ1-maleimide functionalized probe; induces proteasomal degradation of BRD4

Nom chimique ou matériau
(S)-N-(2-(2-(2-(2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamido)ethoxy)ethoxy)ethyl)-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamide
Quantité
10 mg
Cible
Active Degraders
Formule moléculaire
C35H42ClN7O6S
Pureté
95%
Marque
Tocris Bioscience

(+)-JQ1 maleimide is a probe that comprises a cysteine-reactive maleimide connected to the BRD4 ligand, JQ1, via a PEG2 linker. It can be used in the COFFEE method (COvalent Functionalization Followed by E3 Electroporation) in which (+)-JQ1 maleimide is covalently attached to VHL followed by electroporation into live cells. The E3 ligase forms a complex with BRD4 intracellularly and induces its degradation.

Caractéristiques techniques

MarqueTocris Bioscience
Réf. B-LABOBL-RE-126179
Réf. fabricant18015552
Nom chimique ou matériau(S)-N-(2-(2-(2-(2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamido)ethoxy)ethoxy)ethyl)-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamide
Quantité10 mg
CibleActive Degraders
Formule moléculaireC<sub>35</sub>H<sub>42</sub>ClN<sub>7</sub>O<sub>6</sub>S
Pureté95%
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