Highly potent ALK inhibitor; also potently inhibits IR, IGF1R, STK22D and FLT3
Ceritinib is a highly potent anaplastic lymphoma kinase (ALK) inhibitor (IC50 = 0.2 nM). Also displays potent inhibition of insulin receptor (IR), insulin-like growth factor receptor 1 (IGF1R), serine/threonine-protein kinase STK22D and FLT3 (IC50 values are 7, 8, 23 and 60 nM, respectively). Inhibits tumor growth in Karpas299 and H2228 rat xenograft models.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-126244 |
| Réf. fabricant | 18759016 |
| Synonyme | LDK378 |
| Quantité | 50 mg |
| Formule moléculaire | C<sub>28</sub>H<sub>36</sub>ClN<sub>5</sub>O<sub>3</sub>S |
| Poids de la formule | 558.14 |
| Type de produit | Inhibitor |
| Pureté | 98% |
