Disrupts MTDH and SND1 interaction, enhances immune surveillance
C26-A2 inhibits the interaction between MTDH and SND1 by blocking the SND1 pocket. C26-A2 disrupts MTDH-SND1 complex-induced reduction in tumor antigen presentation and T cell infiltration; enhancing immune surveillance and sensitivity to anti-PD-1 therapy in metastatic breast cancer mouse models. C26-A6 suppresses tumor growth (IC50 = 12.3 μM) and metastasis and enhances chemotherapy sensitivity in triple-negative breast cancer (TNBC) mouse models.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-126277 |
| Réf. fabricant | 18795816 |
| Nom chimique ou matériau | 5-Chloro-2-methoxy-N-(2-methyl[1,2,4 ]triazolo[1,5-a]pyridin-8-yl)benzenesulfonamide |
| CAS | 1341030-00-9 |
| Quantité | 10 mg |
| Cible | Cell Adhesion Inhibitors |
| Formule moléculaire | C<sub>14</sub>H<sub>13</sub>ClN<sub>4</sub>O<sub>3</sub>S |
| Pureté | 0.98 |
