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Tocris Bioscience™ VU 0424465

Name: Tocris Bioscience™ VU 0424465
Brand: Tocris Bioscience
SKU: 18766126
Price: 247.29 EUR
Availability: InStock

Réf. : BL-RE-126359Réf. fabricant : 18766126 10 mg

247,29 € HT

Potent mGlu5 positive allosteric modulator and agonist; binds allosteric site with high affinity

Nom chimique ou matériau: 5-[2-(2-(3-Fluorophenyl)ethynyl]-N-[(1R)-2-hydroxy-1,2-dimethylpropyl]-2-pyridinecarboxamide
CAS: 1428630-85-6
Quantité: 10 mg
Formule moléculaire: C₁₉H₁₉FN₂O₂
Pureté: 98%
Marque: Tocris Bioscience

VU 0424465 is a potent mGlu5 positive allosteric modulator (EC50 = 1.5 nM) and agonist (EC50 = 171 nM; maximum effect is 65% that of glutamate). Binds allosteric site with high affinity (Ki = 11.8 nM). Increases maximum response to glutamate by 30%. Exhibits bias towards signaling via IP1 and ERK1/2 over iCa2+ in HEK293 and neuronal cells, and activates Gs in HEK 293 cells. Induces epileptiform activity in CA3 hippocampal neurons

in vitro

and convulsions

in vivo

Caractéristiques techniques

Marque	Tocris Bioscience
Réf. B-LABO	BL-RE-126359
Réf. fabricant	18766126
Nom chimique ou matériau	5-[2-(2-(3-Fluorophenyl)ethynyl]-N-[(1R)-2-hydroxy-1,2-dimethylpropyl]-2-pyridinecarboxamide
CAS	1428630-85-6
Quantité	10 mg
Formule moléculaire	C<sub>19</sub>H<sub>19</sub>FN<sub>2</sub>O<sub>2</sub>
Pureté	98%

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Tocris Bioscience™ VU 0424465

Caractéristiques techniques

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