SAG (Smoothened Agonist) is a chlorobenzothiophene-containing compound which acts as an activator of the G protein-coupled receptor Smoothened (SMO, EC50 = 3 nM; Chen et al.) SMO is a component of the Hedgehog signaling pathway, which is translocated to the primary cilium after stimulation of the Patched receptor by Hedgehog family ligands, leading to pathway activation
SAG activates SMO via direct binding to the heptahelical bundle (Kd= 59 nM), stabilizing a specific conformation of SMO in cilia and leading to increased downstream gene expression (Rohatgi et al.) SAG abrogates cyclopamine inhibition of SMO, indicating that it acts downstream of cyclopamine (Frank-Kamenetsky et al.; Chen et al.; Lewis & Krieg)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-126378
Réf. fabricant
17120222
CAS
912545-86-9
Synonyme
Smoothened Agonist
Quantité
10 mg
Formule moléculaire
C<sub>28</sub>H<sub>28</sub>ClN<sub>3</sub>OS
Pureté
≥98%
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