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STEMCELL Technologies CHIR99021 | B-LABO France
STEMCELL Technologies CHIR99021
Réf. : BL-RE-126389Réf. fabricant : 15672517 1 mg
135,00 € HT
WNT pathway activator; Inhibits GSK3
CAS
252917-06-9
Synonyme
CT 99021
Quantité
1 mg
Formule moléculaire
C22H18Cl2N8
Pureté
≥95%
Marque
STEMCELL Technologies
Caractéristiques principales
CHIR99021 is an aminopyrimidine derivative that is an extremely potent glycogen synthase kinase (GSK) 3 inhibitor, inhibiting both GSK3β (IC50 = 6.7 nM) and GSK3α (IC50 = 10 nM)
GSK3 is a serine/threonine kinase that is a key inhibitor of the WNT pathway; therefore CHIR99021 functions as a WNT activator
It shows little activity against a large panel of kinases including CDK2 and other serine/threonine kinases such as MAPK and PKB
