SB431542 is a selective and potent inhibitor of the TGF-β/Activin/NODAL pathway that inhibits ALK5 (IC50 = 94 nM), ALK4 (IC50 = 140 nM), and ALK7 by competing for the ATP binding site
It does not inhibit the BMP type I receptors ALK2, ALK3, and ALK6
This product is supplied as the hydrate form of the molecule
