TTNPB is an analog of retinoic acid that potently and selectively activates retinoic acid receptors (RAR; EC50 = 21, 4, and 2.4 nM for RARα, RARβ, and RARγ, respectively; Beard et al.; Wong et al.)
In combination with CHIR99021 or Activin A, induces intermediate mesoderm formation from human or mouse pluripotent stem cells, respectively (Araoka et al.; Oeda et al.)
Promotes neuronal differentiation in cultured chick caudal neural plate explants (Diez del Corral et al.)
Enables chemical reprogramming (without genetic factors) of mouse embryonic fibroblasts to induced pluripotent stem (iPS) cells, in combination with CHIR99021, Tranylcypromine, VaLproic Acid, 3-Deazaneplanocin A, and E-616452 (Hou et al.)
Induces the in vitro growth and differentiation to granulocytes of myeloid progenitors isolated from myelodysplastic syndrome (MDS) patients (Fabian et al.)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-126407
Réf. fabricant
17150142
CAS
71441-28-6
Synonyme
AGN 191183; Arotinoid Acid; Ro 13-7410
Quantité
10 mg
Formule moléculaire
C<sub>24</sub>H<sub>28</sub>O<sub>2</sub>
Pureté
≥98%
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