BMP and AMPK pathway inhibitor; Inhibits ALK2, ALK3, ALK6, and AMPK
CAS
866405-64-3
Synonyme
Compound C
Quantité
50 mg
Formule moléculaire
C24H25N5O
Pureté
≥98%
Marque
STEMCELL Technologies
Caractéristiques principales
Dorsomorphin inhibits the bone morphogenetic protein (BMP) pathway by targeting the type I BMP receptors activin receptor-like kinase (ALK) 2, ALK3, and ALK6
It is also a potent inhibitor of AMP-activated protein kinase (AMPK; Ki = 109 nM) but does not significantly inhibit structurally related kinases such as ZAPK, SYK, PKCθ, PKA, or JAK3 (Bain et al.), Yu et al.)
Promotes differentiation of neural progenitor cells from human pluripotent stem cells (Morizane et al.), Zhou et al.)
Promotes differentiation of cardiomyocytes from mouse and human pluripotent stem cells (Hao et al.), Kattman et al.)
Promotes differentiation of adipocytes and suppresses osteogenic differentiation of osteoblasts from human mesenchymal cells (Kim et al.)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-126436
Réf. fabricant
17119971
CAS
866405-64-3
Synonyme
Compound C
Quantité
50 mg
Formule moléculaire
C<sub>24</sub>H<sub>25</sub>N<sub>5</sub>O
Pureté
≥98%
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