Inhibitor of WNT Production-3 (IWP-3) inhibits WNT signaling by inactivating Porcupine, a membrane-bound O-acyltransferase responsible for palmitoylating WNT proteins, which is essential for WNT signaling ability and secretion (Chen et al.) IWP-3 impairs WNT pathway activity in vitro with an IC50 value of 40 nM (Chen et al.)
Promotes cardiomyocyte differentiation from human embryonic stem cells that have been induced to mesoderm by addition of BMP4 and Activin A (Willems et al.)
