Prostaglandin E2 (PGE2) is the most biologically active and well-studied prostaglandin
It binds with very high affinity to the EP1, EP2, EP3, and EP4 receptors (Ki = 9.1, 4.9, 0.33, 0.79 nM respectively)
(Abramovitz et al.), Bos et al.)
Required for the development of hematopoietic stem cells (HSCs) in mice and zebrafish (North et al.)
Improves engraftment of mouse HSCs, possibly through increasing homing, survival, and/or self-renewal (Hoggatt et al. 2009, Hoggatt et al.) 2013, North et al.)
Promotes differentiation of hematopoietic progenitor cells from mouse, macaque, and human embryonic stem cells (Gori et al.), North et al.), Woods et al.)
Promotes differentiation of myeloid-derived suppressor cells from hematopoietic progenitors (Sinha et al.)
Promotes differentiation of Th17 cells from naïve T-cells (Boniface et al.)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-126470
Réf. fabricant
15692517
CAS
363-24-6
Synonyme
Dinoprostone; PGE2
Quantité
1 mg
Formule moléculaire
C<sub>20</sub>H<sub>32</sub>O<sub>5</sub>
Pureté
≥98%
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