Epigenetic modifier; Inhibitor of Sir2p, SIRT1, and SIRT2
CAS
410536-97-9
Synonyme
Sir Two Inhibitor Naphthol
Quantité
10 mg
Formule moléculaire
C26H22N2O2
Pureté
≥98%
Marque
STEMCELL Technologies
Caractéristiques principales
Sirtinol is a cell-permeable inhibitor of sirtuin NAD+-dependent histone deacetylases (HDACs), including yeast Sir2p (IC50 = 68 μM; Grozinger et al.), human SIRT1 (IC50 = 131 μM; Schuetz et al.), and SIRT2 (IC50 = 38 μM; Grozinger et al.) It does not inhibit human HDAC1 activity (Grozinger et al.) Sirtinol also activates the auxin signaling pathway in Arabidopsis (Dai et al.)
Suppresses inflammatory signaling in human dermal microvascular endothelial cells (Orecchia et al.)
Enhances apoptosis and cell death in leukemic cells, but not in healthy leukocytes and hematopoietic progenitors (Cea et al.)
Induces senescence-like growth arrest in human cancer cell lines MCF-7 and H1299 (Ota et al.; Wang et al.)
