Inducer of definitive endoderm 2 (IDE2) induces differentiation of mouse or human pluripotent stem cells (PSCs) by activating SMAD2 phosphorylation and NODAL expression (Borowiak et al.) At EC50 = 223nM, SOX17 expression was induced in mouse ES cells
Induces definitive endoderm from mouse or human ES cells in the absence of Activin A, NODAL, or feeder cells (Borowiak et al.)
