Pifithrin-mu (PFT-μ) is an inhibitor of p53-mediated apoptosis, preventing p53 binding to Bcl-xL and Bcl-2 at the mitochondrial surface, without affecting p53 transactivational activities (Strom et al.) In vitro, PFT-μ binds both p53 (Kd = 0.82 mM) and Bcl-xL (Kd = 0.80 mM; Hagn et al.)
In combination with Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor Y-27632, improves cell recovery after cryopreservation (Xu et al.)
Inhibits DNA damage-induced apoptosis in human embryonic stem cells (Qin et al.)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-126519
Réf. fabricant
17190122
CAS
64984-31-2
Synonyme
2-Phenylethynesulfonamide; PFT-μ; Pifithrin-μ
Quantité
10 mg
Formule moléculaire
C<sub>8</sub>H<sub>7</sub>NO<sub>2</sub>S
Pureté
≥98%
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