Inhibitor of WNT Production-4 (IWP-4) inhibits WNT signaling by inactivating Porcupine, a membrane-bound O-acyltransferase responsible for palmitoylating WNT proteins, which is essential for WNT signaling ability and secretion (Chen et al.) IWP-4 impairs WNT pathway activity in vitro with an IC50 value of 25 nM (Chen et al.)
Promotes cardiomyocyte differentiation in human pluripotent stem cells after treatment with CHIR99021 (Lian et al.), 2012, 2013; Sequiera et al.)
Promotes cardiomyocyte differentiation in human embryonic stem cells following primitive streak induction with BMP4 and Activin A (Hudson et al.)
