FK506 is a macrolide antibiotic with potent immunosuppressive properties (Thomson et al.) It inhibits the calcineurin/NFAT pathway (Martinez-Martinez & Redondo) and binds with high affinity to FK506 binding protein 12 (FKBP-12) (Thomson et al.)
Promotes the self-renewal of mouse embryonic stem cells independent of leukemia inhibitory factor (LIF), and attenuates differentiation following LIF withdrawal (Li et al.)
In combination with 1-Azakenpaullone (Catalog #74252) and ID-8 (Catalog #72502), enhances the expansion rates of several human pluripotent stem cell lines (Yasuda et al.)
Inhibits pro-inflammatory cytokine production by activated T cells (Sakuma et al.)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-126529
Réf. fabricant
17190332
CAS
104987-11-3
Synonyme
Tacrolimus
Quantité
50 mg
Formule moléculaire
C<sub>44</sub>H<sub>69</sub>NO<sub>12</sub>
Pureté
≥99%
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