Caractéristiques principales
- SB203580 (Hydrochloride) is a potent inhibitor of p38 MAPK activity (IC50 = 0.6 μM)
- It inhibits both the α and β isoforms of p38 MAPK, and does not inhibit ERK or JNK
- (Bain et al.), Cuenda et al.)
- Enhances the growth and self-renewal of mouse embryonic stem (ES) cells (Qi et al.)
- Promotes long-term maintenance of human naïve ground state pluripotent stem cells (Gafni et al.)
- Promotes proliferation of human endothelial progenitor cells (Seeger et al.)
- Promotes proliferation of neonatal and adult rat cardiomyocytes (Engel et al.)
- Enhances differentiation of cardiomyocytes from human ES cells (Gaur et al.), Graichen et al.)
- Inhibits differentiation of cardiomyocytes from mouse ES cells by inhibition of early mesoderm (Davidson and Morange)
Caractéristiques techniques
| Marque | STEMCELL Technologies |
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| Réf. B-LABO | BL-RE-126537 |
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| Réf. fabricant | 17160042 |
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| CAS | 869185-85-3 |
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| Synonyme | PB 203580; RWJ 64809 |
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| Quantité | 5 mg |
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| Formule moléculaire | C<sub>21</sub>H<sub>16</sub>FN<sub>3</sub>OS · HCl |
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| Pureté | ≥98% |
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