BIO is an indirubin compound that is cell-permeable and is a selective and potent reversible inhibitor of GSK3α and GSK3β (IC50 = 5 nM) and functions as a WNT activator
Enhances reprogramming of mouse fibroblasts, neural stem cells, and thymocytes to induced pluripotent stem (iPS) cells (Lluis et al.)
Maintains self-renewal of mouse embryonic stem (ES) cells in the absence of LIF (Sato et al.)
Maintains self-renewal of human ES cells in unconditioned medium through a SMAD 2/3 dependent mechanism (James et al.), Sato et al.)
Induces proliferation of neonatal and adult rat cardiomyocytes (Tseng et al.)
Promotes differentiation of cardiomyocytes from human ES and iPS cells (Lian et al.)
