STO-609 is a cell-permeable, selective inhibitor of ATP-competitive calcium/calmodulin-dependent kinase kinases (CaMKK)
STO-609 inhibits the activities of recombinant isoforms CaMKKα (Ki = 80 ng/mL) and CaMKKβ (Ki = 15 ng/mL) and also inhibits their autophosphorylation (Kukimoto-Niino et al.; Tokumitsu et al.) STO-609 reduces thrombin-induced nuclear localization of NF-κB activation in endothelial cells (Bair et al.) This product is supplied as the acetate salt form of the molecule
Stimulates osteoblast formation and inhibits osteoclast differentiation in mouse mesenchymal stem cells, and reverses age-associated decline in bone mass (Cary et al.; Pritchard et al.)
Decreases in vitro growth of human hepatic cancer cell lines, and decreases tumor burden in mouse hepatic tumor model (Lin et al.)
