TWS119 is a potent disubstituted pyrrolopyrimidine inhibitor of glycogen synthase kinase 3 beta (GSK3β) with an IC50 of 30 nM and Kd of 126 nM (Ding et al.) GSK3 is a serine/threonine kinase that is a key inhibitor of the WNT pathway; therefore TWS119 functions as a WNT pathway activator
Maintains the bi-potent, quiescent state in hepatic stellate cells of Wistar rats (Kordes et al.)
Induces differentiation of mouse embryonal carcinoma and embryonic stem cells to neurons (Ding et al.)
Induces production of T memory stem cell-like (T-SCM) cells from mouse or human CD8+ T cells with evidence of increased persistence, proliferation, and anti-tumor activity after adoptive transfer of mouse-derived T-SCM (Forget et al.; Gattinoni et al.)
Inhibits cell proliferation and induces apoptosis in human alveolar rhabdomyosarcoma cells (Zeng et al.)
