Fluprostenol is a metabolically stable analog of prostaglandin F2α (PGF2α) with potent PGF2α receptor agonist activity (Abramovitz et al.) Fluprostenol competitively binds to human and rat PGF2α receptors with IC50 values of 3.5 and 7.5 nM, respectively (Abramovitz et al.; Lake et al.)
Inhibits adipose differentiation of newborn rat adipocyte precursors in primary culture (Serrero & Lepak)
Inhibits endothelin–induced contraction of the trabecular meshwork in bovine ocular tissue in vitro, a model of intraocular pressure in glaucoma (Thieme et al.)
