STEMCELL Technologies Ruxolitinib

Name: STEMCELL Technologies Ruxolitinib
Brand: STEMCELL Technologies
SKU: 17190212
Price: 93.15 EUR
Availability: InStock

Réf. : BL-RE-126586Réf. fabricant : 17190212 1 mg

93,15 € HT

JAK/STAT pathway inhibitor; Inhibits JAK1 and JAK2

CAS: 941678-49-5
Synonyme: INCB 018424, INC 424
Quantité: 1 mg
Formule moléculaire: C₁₇H₁₈N₆
Pureté: ≥98%
Marque: STEMCELL Technologies

Caractéristiques principales

Ruxolitinib is an ATP mimic that inhibits all Janus-associated kinase (JAK) family kinases with a preference for JAK-1 and JAK-2 over JAK-3 and TYK2 with IC50 values of 3.3, 2.8, 428 and 19 nM respectively (Verstovsek; Quintás-Cardama et al.)

Suppresses erythroid progenitor colony formation from peripheral blood mononuclear cells of polycythemia vera patients with the constitutively active JAK2 V617F mutation

Reduces malignant cell proliferation and decreases interleukin-6 and TNF-α signaling in a JAK2 V617F-driven mouse model of myeloproliferative disorder (Quintás-Cardama et al.)

Promotes hair regrowth in a mouse model of alopecia areata (Xing et al.)

Caractéristiques techniques

Marque	STEMCELL Technologies
Réf. B-LABO	BL-RE-126586
Réf. fabricant	17190212
CAS	941678-49-5
Synonyme	INCB 018424, INC 424
Quantité	1 mg
Formule moléculaire	C<sub>17</sub>H<sub>18</sub>N<sub>6</sub>
Pureté	≥98%