Tyrosine kinase inhibitor; Inhibits EGFR, HER2, JAK2, JAK3, and STAT5a/b
CAS
133550-30-8
Synonyme
Tyrphostin AG-490
Quantité
10 mg
Formule moléculaire
C17H14N2O3
Pureté
≥98%
Marque
STEMCELL Technologies
Caractéristiques principales
AG-490 is a member of the tyrphostin family of small molecule inhibitors of tyrosine kinases including EGFR (Gazit et al.), HER2 (Gazit et al.), JAK2 (Burger et al.), JAK3 (Brown et al.), and STAT5a/b (Wang et al.) with IC50 values of 0.1, 13.5, 11 and 12 μM, respectively
AG-490 does not inhibit LCK, LYN, BTK, SYK, or SRC tyrosine kinases (Meydan et al.)
