GW2580 is a selective inhibitor of cFMS kinase (IC50 = 0.03 μM) (Conway et al.), 2008), blocking its ability to autophosphorylate colony-stimulating factor (CSF-1 or M-CSF), which promotes the survival, proliferation, and differentiation of macrophages
Demonstrates the importance of CSF-1 in promoting myeloid lineage bias in mouse hematopoietic stem cells (Mossadegh-Keller et al.)
Demonstrates the importance of CSF-1 in expansion of mouse and human macrophage colonies and monocytes (He et al.; Clanchy et al.; Conway et al.), 2008; Conway et al.), 2005)
Inhibits bone degradation in cultures of human osteoclasts, rat calvaria, and rat fetal long bone (Conway et al.), 2005), and in mouse models of arthritis (Conway et al.), 2008)
