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STEMCELL Technologies Perhexiline Maleate | B-LABO France
STEMCELL Technologies Perhexiline Maleate
Réf. : BL-RE-126637Réf. fabricant : 17129991 5 mg
91,80 € HT
Carnitine palmitoyltransferase 1 (CPT1) and CPT2 inhibitor
CAS
6724-53-4
Quantité
5 mg
Formule moléculaire
C19H35N · C4H4O4
Pureté
≥95%
Marque
STEMCELL Technologies
Caractéristiques principales
Perhexiline Maleate is an inhibitor of the mitochondrial enzymes carnitine palmitoyltransferase 1 (CPT1; IC50 = 0.077 mM in rat heart; IC50 = 0.148 mM in rat liver) and CPT2 (IC50 = 0.079 mM in rat heart; Kennedy et al. 1996; Kennedy et al.) 2000)
Perhexiline Maleate also modulates autophagy via mammalian target of rapamycin complex 1 (mTORC1) signaling (Balgi et al.)
Alters myocardial metabolism from fatty acid to glucose utilization, resulting in higher ATP production and oxygen consumption (Ashrafian et al.; Jeffrey et al.)
Inhibits mTORC1 signaling and induces autophagy in MCF-7 cells (Balgi et al.)
