NF-kB, AMPK, and tyrosine kinase pathway inhibitor; Inhibits tyrosine kinase, topoisomerase II and activates PPARγ
CAS
446-72-0
Quantité
100 mg
Formule moléculaire
C15H10O5
Pureté
≥98%
Marque
STEMCELL Technologies
Caractéristiques principales
Genistein is a phytoestrogen that exhibits a wide range of biological effects
It acts by competing for the ATP-binding site of tyrosine kinases but does not inhibit the activity of serine- and threonine-specific kinases such as cAMP-dependent protein kinase, protein kinase C, and phosphorylase kinase (Akiyama et al.) Genistein binds to and activates peroxisome proliferator-activated receptor-gamma (PPARγ) and estrogen receptors, leading to a decrease in osteogenesis and an increase in adipogenesis (Dang et al.) Genistein also binds and activates the seven-transmembrane estrogen receptor GPR30 to activate alternative estrogen signaling pathways (Thomas & Dong)
Inhibits adipocyte differentiation in 3T3-L1 cell culture (Hwang et al.)
Control of osteoblast and adipocyte cell fates in mouse bone marrow cells (Dang et al.)
Inhibits growth of leukemia, lymphoma, neuroblastoma, gastric, breast, and prostate cancer cells (Sarkar & Li)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-126639
Réf. fabricant
17110012
CAS
446-72-0
Quantité
100 mg
Formule moléculaire
C<sub>15</sub>H<sub>10</sub>O<sub>5</sub>
Pureté
≥98%
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