HPI-1 is a Hedgehog (HH) pathway inhibitor that suppresses signaling through Sonic HH (IC50 = 1.5 μM) without significantly affecting WNT signaling (IC50 ≥ 30 μM) (Hyman et al.) HPI-1 suppresses HH activation induced by loss of Suppressor of Fused or by Gli overexpression, suggesting action at posttranslational modification of GLI protein or at the interaction of GLI with a co-factor (Hyman et al.)
Demonstrates the importance of Hedgehog pathway by inhibiting proliferation mediated by the oncogenic Smoothened (SMO) mutant, SMOM2 in cultured cerebellar granule neuron precursor cells (Hyman et al.)
Reduces growth of MDA-MB-231 breast cancer cells (Kwon et al.)
