Inhibitor of bone resorption; Inhibits farnesyl diphosphate (FPP) synthase
CAS
165800-06-6
Synonyme
Zoledronate
Quantité
50 mg
Formule moléculaire
C5H10N2O7P2 · H2O
Pureté
≥95%
Marque
STEMCELL Technologies
Caractéristiques principales
Zoledronic acid is a nitrogen-containing bisphosphonate that inhibits farnesyl diphosphate (FPP) synthase (IC50 = 5 nM), thereby preventing protein prenylation and osteoclast-mediated bone resorption (Dunford et al.) In addition, it has a high affinity for hydroxyapatite (Ki = 3.5 μM) which allows it to bind directly to mineralized bone (Nancollas et al.) This product is supplied as the hydrate form of the molecule
Inhibits proliferation, angiogenesis, and adhesion to bone, in several cancer cell lines (Li & Davis; Zekri et al.)
Inhibits breast and prostate carcinoma cell invasion in vitro (Boissier et al.; Li & Davis)
Induces apoptosis of osteoclastoma cells in vitro (Benford et al.)
