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STEMCELL Technologies Compound E | B-LABO France
STEMCELL Technologies Compound E
Réf. : BL-RE-126673Réf. fabricant : 17110302 1 mg
504,90 € HT
Notch pathway inhibitor; Inhibits Notch receptor and amyloid precursor protein
CAS
209986-17-4
Synonyme
γ-secretase inhibitor XXI
Quantité
1 mg
Formule moléculaire
C27H24F2N4O3
Pureté
≥98%
Marque
STEMCELL Technologies
Caractéristiques principales
Compound E is a potent, cell-permeable, selective inhibitor that blocks the cleavage of both gamma-secretase and the Notch intracellular domain with similar IC50 values, ranging from 0.24 to 0.37 nM (Beher et al.; Seiffert et al.)
Inhibits growth, differentiation, and motility of neuroblastoma cells (Ferrari-Toninelli et al.)
Accelerates the differentiation of human embryonic stem cells into primitive neural stem cells (Li et al.)
