Activin/NODAL/TGF-β pathway inhibitor; Inhibits ALK5, ALK4, and ALK7
CAS
909910-43-6
Quantité
10 mg
Formule moléculaire
C25H19N5S
Pureté
≥95%
Marque
STEMCELL Technologies
Caractéristiques principales
A 83-01 is a potent inhibitor of activin receptor-like kinase (ALK) including ALK5 (type I transforming growth factor-β receptor), ALK4 (type IB activin receptor), and ALK7 (type I NODAL receptor) with IC50 = 12, 45, and 7.5 nM, respectively (Tojo et al.)
Facilitates the conversion of epiblast stem cells to the naїve pluripotent state (Zhou et al.; Li et al.)
In combination with PD0325901, enables OCT4-mediated reprogramming (Zhu et al.)
Inhibits mesoderm and endoderm specification (Zhang et al.)
Disrupts epithelial to mesenchymal transition through inhibition of the SMAD signaling pathway (Tojo et al.)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-126687
Réf. fabricant
17160012
CAS
909910-43-6
Quantité
10 mg
Formule moléculaire
C<sub>25</sub>H<sub>19</sub>N<sub>5</sub>S
Pureté
≥95%
Une question, une configuration particulière ? Contactez-nous pour un devis.
