ID-8 is an indole derivative (Miyabayashi et al.) that inhibits members of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family (Hasegawa et al.)
Enables maintenance of mouse embryonic stem (ES) cells in the absence of mouse embryonic fibroblast (MEF) feeder cells, serum, or LIF (Miyabayashi et al.)
In combination with Wnt, supports human ES cell proliferation and survival, without FGF or TGFβ (Hasegawa et al.)
