Antibiotic with anti-inflammatory and neuroprotective properties
Synonyme
Minomycin; NSC 141993
Quantité
100 mg
Formule moléculaire
C23H27N3O7 · HCl · XH2O
Pureté
≥98%
Marque
STEMCELL Technologies
Caractéristiques principales
Minocycline is a semi-synthetic tetracycline and antibiotic broadly used to treat various bacterial infections
It inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit
It has also been reported to chelate with Ca2+ and Mg2+ (Lambs et al.) Reported to be anti-inflammatory, immunomodulatory, and neuroprotective (Garrido-Mesa et al.), some of its mechanism of actions include inhibiting enzymatic activities of inducible nitric oxide synthase (Amin et al.), matrix metalloproteinases (Golub et al.), and phospholipase A2 (Pruzanski et al.), inhibiting activation of caspase-1 and caspase-3 (Chen et al.), inhibiting activity of poly(ADP-ribose) polymerase 1 (Alano et al.), and reduction of p38 MAPK phosphorylation (Corbacella et al.) This product is supplied as the hydrochloride salt of the molecule
