AZD8055 is a potent, selective ATP-competitive inhibitor of mammalian target of rapamycin (mTOR), with an IC50 value of 0.8 nM (Chresta et al.) It is very specific with ∼1,000-fold selectivity for mTOR over all PI3K isoforms and exhibits no activity against a panel of 260 kinases at concentrations up to 10 μM (Chresta et al.)
