"/>
STEMCELL Technologies Rho Kinase Inhibitor IV (Dihydroch… | B-LABO France
STEMCELL Technologies Rho Kinase Inhibitor IV (Dihydrochloride)
Réf. : BL-RE-126756Réf. fabricant : 17100282 1 mg
364,50 € HT
RHO/ROCK pathway inhibitor; Inhibits ROCK2
CAS
67-56-1
Synonyme
(S)-Glycyl-H-1152
Quantité
1 mg
Formule moléculaire
C18H24N4O3S · 2HCl
Pureté
≥98%
Marque
STEMCELL Technologies
Caractéristiques principales
Rho Kinase Inhibitor IV is a selective and potent inhibitor of Rho-associated coiled-coil containing protein kinase 2 (ROCK2; IC50 = 11.8 nM; Tamura et al.) It is a glycyl analog of Fasudil (Catalog #73662) with increased specificity for ROCK2 (Tamura)
Rho Kinase Inhibitor IV is more potent than other ROCK inhibitors, including Y-27632 (Ki = 220 nM) and Fasudil (IC50 = 158 nM)
It shows good specificity for ROCK2 compared to other kinases such as calcium/calmodulin-dependent kinase type II (IC50 = 2.57 μM), PKG (IC50 = 2.35 μM), Aurora A (IC50 = 3.26 μM), or PKA or PKC (IC50 ≥ 10 μM each)
ROCK1 and ROCK2 act downstream of the G protein Rho to regulate actin-myosin turnover and dynamics, and play an important role in stem cell renewal, smooth muscle contraction, cell adhesion, and proliferation (Narumiya et al.; Olson; Watanabe et al.) This product is supplied as the dihydrochloride salt of the molecule
