NAMPT Inhibitors
STF 118804 is a NAMPT inhibitor (nicotinamide phosphoribosyltransferase, visfatin, PBEF1); inhibits NAD+ synthesis from nicotinamide. Potently inhibits the viability of multiple B-cell acute lymphoplastic leukemia (B-ALL) cell lines (IC50 < 10 nM); induces apoptosis in MF-411 cells. Induces regression of ALL xenografts and eliminates leukemia stems cells from bone marrow in mice.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-126776 |
| Réf. fabricant | 18790809 |
| Nom chimique ou matériau | 4-[5-Methyl-4-[[(4-methylphenyl)sulfonyl]methyl]-2-oxazolyl]-N-(3-pyridinylmethyl)benzamide |
| CAS | 894187-61-2 |
| Plage de pourcentage du dosage | >98% |
| Quantité | 5 mg |
| Formule moléculaire | C<sub>25</sub>H<sub>23</sub>N<sub>3</sub>O<sub>4</sub>S |
| Poids de la formule | Observed MW: 461.53 |
