Selective ATP competitive sphingosine kinase 2 and 1 (SphK2/1) inhibitor
MP A08 is a selective ATP competitive sphingosine kinase 2 and 1 (SphK2/1) inhibitor (Ki values are 6.9 and 27 μM, respectively). Exhibits selectivity for SphK 1 and 2 over other kinases. Inhibits cellular S1P production and increases sphingosine and ceramide levels
in vitro
. Also induces mitochondrial-associated apoptosis. Reduces tumor growth in a human lung adenocarcinoma xenograft mouse model, by inducing apoptosis and suppressing angiogenesis. Cell permeable.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-126790 |
| Réf. fabricant | 18785586 |
| Nom chimique ou matériau | 4-Methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]benzenesulfonamide |
| CAS | 219832-49-2 |
| Synonyme | NSC 122314 |
| Quantité | 50 mg |
| Formule moléculaire | C<sub>27</sub>H<sub>25</sub>N<sub>3</sub>O<sub>4</sub>S<sub>2</sub> |
| Poids de la formule | 519.64 |
