Potent CXCR1 and CXCR2 allosteric antagonist
Reparixin L-lysine salt is a potent and noncompetitive CXCR1 and CXCR2 allosteric antagonist (IC50 = 1 nM for inhibition of CXCL8-induced human polymorphonuclear cell migration). Also inhibits migration of rodent neutrophils induced by CXCL1, CXCL2, CXCL8 and CINC-1. Inhibits vascular permeability and neutrophil recruitment in
in vivo
models of mild and severe ischemia/reperfusion injury. Also selectively depletes cancer stem cells in human breast cancer cell lines and xenograft models.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-126797 |
| Réf. fabricant | 18796336 |
| CAS | 266359-93-7 |
| Synonyme | Repertaxin L-lysine salt |
| Quantité | 10 mg |
| Solubilité | Soluble to 50 mM in DMSO and to 5 mM in water with gentle warming |
| Formule moléculaire | C<sub>14</sub>H<sub>21</sub>NO<sub>3</sub>S.C<sub>6</sub>H<sub>14</sub>N<sub>2</sub>O<sub>2</sub> |
| Poids de la formule | 429.58 |
| Type de produit | Antagonist |
| Pureté | 98% |
