Positive allosteric modulator of MC3 receptors; exhibits biased signaling
Fenoprofen calcium is a melanocortin 3 (MC3) receptor positive allosteric modulator (PAM; allosteric enhancer) (pEC50 = 8.69); decreases the EC50 of α-MSH at MC3R. Stimulates ERK1/2 activation at MC3-5R, with highest ERK1/2 activation observed at 3 and 10 μM for MC3R, 1 μM for MC4R, and 3 μM for MC5R. Exhibits biased signaling at MC3-5R, selectively activating ERK1/2 cascade but not canonical cAMP signaling. Antiarthritic.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-126807 |
| Réf. fabricant | 18749456 |
| Nom chimique ou matériau | α-Methyl-3-phenoxybenzeneacetic acid hemicalcium salt |
| CAS | 34597-40-5 |
| Quantité | 50 mg |
| Formule moléculaire | C<sub>15</sub>H<sub>13</sub>O<sub>3</sub>.0.5Ca |
| Poids de la formule | 261.31 |
| Type de produit | Positive Allosteric Modulator |
| Pureté | 98% |
