NAV 2729 is a selective ARF6 inhibitor (IC50 = 1.0 μM). Selective for ARF6 over other ARF family members and small GTPases. Inhibits ARF6 activation in uveal melanoma cells in vitro and blocks downstream signaling pathways of oncogenic GNAQ. Reduces tumorigenesis in mouse model of uveal melanoma.
- Couleur
- Yellow
- Type de produit
- Inhibitor
- CAS
- 419547-11-8
- Formule moléculaire
- C25H17ClN4O3
- Poids de la formule
- 456.88g/mol
- Solubilité
- Soluble to 100mM in DMSO
- Contenu et stockage
- Store at 4°C
- À utiliser avec (application)
- Blocks downstream signaling pathways
- Quantité
- 10 mg
