The RosetteSep™ Human CD45 Depletion Cocktail is designed to enrich epithelial circulating tumor cells (CTCs) from whole blood by depleting CD45+ cells
Unwanted cells are targeted for depletion with Tetrameric Antibody Complexes recognizing CD45, CD66b and glycophorin A on red blood cells (RBCs)
When centrifuged over a buoyant density medium such as Lymphoprep™ (Catalog #07801), the unwanted cells pellet along with the RBCs
The purified epithelial tumor cells are present as a highly enriched population at the interface between the plasma and the buoyant density medium
