"/> Tocris Bioscience™ CRBN PROTAC™ 14a | B-LABO France

Tocris Bioscience™ CRBN PROTAC™ 14a

Réf. : BL-RE-151114Réf. fabricant : 18759846 5 mg
442,75 € HT

Cereblon Degrader (PROTAC™)

Nom chimique ou matériau
N1-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-N20-(-1-((2 S,4 R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,9,12,18-tetraoxaicosanediamide
CAS
2358775-70-7
Quantité
5 mg
Cible
Active Degraders
Formule moléculaire
C53H72N8O13S
Marque
Tocris Bioscience

CRBN PROTAC® 14a is a cereblon Degrader (PROTAC™). Comprises a ligand for Von Hippel Lindau (VHL) protein joined by a linker to a cereblon targeting ligand. Preferentially degrades cereblon (DC50 = 200 nM in HEK293 cells). Induces rapid and profound cereblon degradation (98% decrease after 8 h at 1 μM in HEK293 cells).

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Caractéristiques techniques

MarqueTocris Bioscience
Réf. B-LABOBL-RE-151114
Réf. fabricant18759846
Nom chimique ou matériauN1-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-N20-(-1-((2 S,4 R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,9,12,18-tetraoxaicosanediamide
CAS2358775-70-7
Quantité5 mg
CibleActive Degraders
Formule moléculaireC<sub>53</sub>H<sub>72</sub>N<sub>8</sub>O<sub>13</sub>S
Pureté0.98
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