BAY 876 is a potent and selective GLUT1 inhibitor (IC50 = 2 nM) that displays selectivity for GLUT1 over GLUT2/3/4 (IC50 values are 10.8, 1.67 and 0.29 μM, respectively). BAY 876 induces cell death in hypoxic conditions
in vitro
and inhibits glucose uptake by Hela-MaTu cells. In ovarian cancer, BAY 876 reduces glycolysis rates and ATP production and inhibits proliferation
in vitro
Caractéristiques techniques
| Marque | Tocris Bioscience |
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| Réf. B-LABO | BL-RE-151118 |
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| Réf. fabricant | 18749246 |
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| Nom chimique ou matériau | N4-[1-[(4-Cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-2,4-quinolinedicarboxamide |
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| CAS | 1799753-84-6 |
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| Quantité | 5 mg |
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| Formule moléculaire | C<sub>24</sub>H<sub>16</sub>F<sub>4</sub>N<sub>6</sub>O<sub>2</sub> |
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| Pureté | 98% |
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